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Binding leads to a rotational change in the receptor transmembrane domain, which leads to transphosphorylation and activation of two JAK2 molecules that are associated with the cytoplasmic domain of the receptor

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Receptor activation may modulate immune cell function, cytokine production, and inflammatory signaling pathways independent of metabolic changes

J Mol Endocrinol 25 , 141148 (2000)

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